野黄芩素 也叫金黄紫 碱
野黄芩素(Scutellarein)
CAS: 529-53-3
化学式: C15H10O6
| 中文名 | 野黄芩素 |
| 英文名 | Scutellarein |
| 别名 | 元參酮 金黄紫碱 野黄芩苷 野黄芩素 野黄芩素 也叫金黄紫 碱 4',5,6,7-四羥黃酮 4',5,6,7-四羟基黄酮 4',5,6,7-四羟基黄酮 5,6,7-三羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮 5,6,7-三羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮 |
| 英文别名 | Scutellarein SCUTELLAREIN isocarthamidin 6-HYDROXYAPIGENIN SCUTELLAREIN WITH HPLC 4',5,6,7-Tetrahydroxyflavone 5,6,7,4'-TETRAHYDROXYFLAVONE 5,6,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one 2-(4-Hydroxyphenyl)-5,6,7-trihydroxy-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one,5,6,7-trihydroxy-2-(4-hydroxyphenyl)- |
| CAS | 529-53-3 |
| EINECS | 1806241-263-5 |
| 化学式 | C15H10O6 |
| 分子量 | 286.24 |
| InChI | InChI=1/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H |
| InChIKey | JVXZRQGOGOXCEC-UHFFFAOYSA-N |
| 密度 | 1.654±0.06 g/cm3(Predicted) |
| 熔点 | 330°C |
| 沸点 | 642.9±55.0 °C(Predicted) |
| 比旋光度 | -14°(water)，-139°(pyridine) |
| 闪点 | 249.9°C |
| 蒸汽压 | 3.97E-17mmHg at 25°C |
| 溶解度 | DMSO: 可溶性1mg/mL，澄清，黄绿色 |
| 折射率 | 1.767 |
| 酸度系数 | 6.34±0.40(Predicted) |
| 存储条件 | Sealed in dry,2-8°C |
| 外观 | 粉末 |
| 颜色 | yellow |
| 物化性质 | 棕色结晶性粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于唇形科韩信草全草,半枝莲全草,紫葳科木蝴蝶;蔷薇科珍梅;菊科;玄参科;唇形科等。 |
| MDL号 | MFCD01861503 |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| 海关编号 | 29329990 |
| 下游产品 | 蓟黄素 |
| 参考资料 展开查看 | 1. 田宇柔[1 3 4] 甄亚钦[1 3 4] 王鑫国[1 3 4] 李军山[2 3 4] 牛丽颖[1 3 4]. 半枝莲配方颗粒HPLC指纹图谱及含量测定方法研究[J]. 中国药学杂志 2016(51):1799. 2. 熊华斌, 阿新祥, 杨欣雨,等. 正交设计在灯盏乙素提取优化中的应用[J]. 北方园艺, 2013(06):164-166. 3. 徐雪林, 赵洁, 易红,等. 灯盏乙素乙酯原料药中主成分含量测定及其有关物质研究[J]. 中国药学杂志, 2015, 50(18):1581-1588. 4. 范书生, 李想, 孙思琪,等. 百里香酚类部位HPLC和UV-Vis法含量测定方法研究[J]. 北京中医药大学学报, 2019, 042(010):854-861. 5. 宋军妹, 惠权斌, 吕文英,等. 银丹心脑通软胶囊定量质量控制提升研究[J]. 中国现代中药, 2017(10):1466-1469. 6. 柯小红. 多裂翅果菊中菊苣酸的分离纯化与微生物转化[D].南京师范大学,2015. 7. 路东波, 高园园, 姜艳艳,等. 基于有效基准特征图谱质量表征模式的中药紫苏叶质量评价研究[J]. 北京中医药大学学报, 2020, 043(002):148-162. 8. 蒋家璐,孙溧,倪姐,徐坠成,宋蒙蒙,姚卫峰,程海波,康安,孙东东.肠道菌群对半枝莲中活性成分的代谢及其抑制CYP1A1酶的影响[J].南京中医药大学学报,2021,37(02):225-230. 9. 纪万里,周泽华,王婷婷,安叡,梁琨,王新宏.基于UPLC-LTQ-Orbitrap-MS方法分析半夏泻心汤化学成分[J].药物分析杂志,2020,40(10):1736-1750. 10. Wang, WW., Lu, L., Bao, TH. et al. Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells. J Mol Neurosci 58, 210–220 (2016). https://doi.org/10.1007/s12031-015-0660-0 11. Chen, Meng, et al. "Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate." Journal of Pharmaceutical and Biomedical Analysis 195 (2021): 113820.https:// 12. [IF=3.935] Liangmian Chen et al."Simultaneous determination of various bioactive redox components in Shuang–Huang–Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system."J Pharmaceut Biomed. 2014 J 13. [IF=3.361] Huanyu Guan et al."Comparative intestinal bacteria-associated pharmacokinetics of 16 components of Shengjiang Xiexin decoction between normal rats and rats with irinotecan hydrochloride (CPT-11)-induced gastrointestinal toxicity in vitro using salting-out 14. [IF=3.046] Liwei Dong et al."Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1."Oncotargets Ther. 2015; 8: 3649–3664 15. [IF=2.678] Wang Wei-Wei et al."Scutellarin Alleviates Behavioral Deficits in a Mouse Model of Multiple Sclerosis, Possibly Through Protecting Neural Stem Cells."J Mol Neurosci. 2016 Feb;58(2):210-220 16. [IF=2.146] Wei-Wei Wang et al."Scutellarin may alleviate cognitive deficits in a mouse model of hypoxia by promoting proliferation and neuronal differentiation of neural stem cells."Iran J Basic Med Sci. 2017 Mar; 20(3): 272–279 17. [IF=1.902] Yining Zhao et al."Simultaneous quantitation of 23 bioactive compounds in Tanreqing capsule by high-performance liquid chromatography electrospray ionization tandem mass spectrometry."Biomed Chromatogr. 2019 Jul;33(7):e4531 18. [IF=1.851] Xinyu Hu et al."Pharmacological basis for application of scutellarin in Alzheimer's disease: Antioxidation and antiapoptosis."Mol Med Rep. 2018 Nov;18(5):4289-4296 19. [IF=7.097] Jiezhou Ye et al."Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signaling."Acta Pharm Sin B. 2021 Jan;11:112 20. [IF=6.023] Ying Liu et al."Mechanistic study of bergamottin-induced inactivation of CYP2C9."Food Chem Toxicol. 2021 Jul;153:112278 21. [IF=5.34] Shusheng Fan et al."Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS."Phytomedicine. 2021 Oct;91:153673 22. [IF=5.11] Xiaonan Liu et al."De Novo Biosynthesis of Multiple Pinocembrin Derivatives in Saccharomyces cerevisiae."Acs Synth Biol. 2020;9(11):3042–3051 23. [IF=4.759] Yueping Jiang et al."Application of multifold characteristic ion filtering combined with statistical analysis for comprehensive profiling of chemical constituents in anti-renal interstitial fibrosis I decoction by ultra-high performance liquid chromatogra 24. [IF=3.935] Meng Chen et al."Comprehensive analysis of Huanglian Jiedu decoction: Revealing the presence of a self-assembled phytochemical complex in its naturally-occurring precipitate."J Pharmaceut Biomed. 2021 Feb;195:113820 25. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 26. [IF=3.361] Fuen Liu et al."Scutellarin ameliorates cartilage degeneration in osteoarthritis by inhibiting the Wnt/β-catenin and MAPK signaling pathways."Int Immunopharmacol. 2020 Jan;78:105954 27. [IF=2.952] Shao-Hua Ju et al."Scutellarin regulates osteoarthritis in vitro by inhibiting the PI3K/AKT/mTOR signaling pathway."Mol Med Rep. 2021 Jan;23(1):1-1 28. [IF=1.552] Fang Mingyue et al."Qualitative and Quantitative Analysis of 24 Components in Jinlianhua Decoction by UPLC–MS/MS."Chromatographia. 2019 Dec;82(12):1801-1825 29. [IF=1.448] Xiaoqin Zhong et al."Scutellarin‑treated exosomes increase claudin 5, occludin and ZO1 expression in rat brain microvascular endothelial cells."Exp Ther Med. 2019 Jul;18(1):33-40 30. [IF=3.935] Yizhu Wang et al."Effects of Scutellaria baicalensis Georgi. on Intestinal Flora in Rats with Spleen Deficiency and Damp-heat."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2022 May;:114831 31. [IF=7.514] Jie Meng et al."Conduction of a chemical structure-guided metabolic phenotype analysis method targeting phenylpropane pathway via LC-MS: Ginkgo biloba and soybean as examples."FOOD CHEMISTRY. 2022 Oct;390:133155 |
野黄芩素 也叫金黄紫 碱 - 介绍
（药理） 具有降低脑血管阻力，改善脑血循环、增加脑血流量及抗血小板凝集的作用。临床用于脑血管病后瘫痪的治疗。
最后更新：2022-10-16 17:25:56
野黄芩素 也叫金黄紫 碱 - 简介
野黄芩素是一种植物次生代谢产物，其化学结构为黄酮类化合物，具有苦味和黄色颜色。它广泛存在于一些植物中，例如黄芩、黄岚、火麻、金银花等。
野黄芩素具有多种生物活性，包括抗氧化、抗菌、抗炎和抗肿瘤等作用。
野黄芩素的制法通常是通过从植物中提取获得。提取的方法可以采用溶剂提取或超临界流体萃取等技术。提取得到的野黄芩素可以通过结晶、分离和纯化来得到纯净的产物。
就安全性而言，野黄芩素被认为是相对安全的。长期和过量使用可能会引发一些不良反应，如肝脏毒性。
野黄芩素具有多种生物活性，包括抗氧化、抗菌、抗炎和抗肿瘤等作用。
野黄芩素的制法通常是通过从植物中提取获得。提取的方法可以采用溶剂提取或超临界流体萃取等技术。提取得到的野黄芩素可以通过结晶、分离和纯化来得到纯净的产物。
就安全性而言，野黄芩素被认为是相对安全的。长期和过量使用可能会引发一些不良反应，如肝脏毒性。
最后更新：2024-04-09 20:45:29
供应商列表
提供多种规格现货供应
产品名: 野黄芩素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IS01401
产地: 北京
包装: 1ml/瓶
规格: IS01401-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
提供多种规格现货供应
产品名: 野黄芩素(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IS01401
产地: 北京
包装: 1ml/瓶
规格: IS01401-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
野黄芩素 也叫金黄紫 碱的下游产品
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！